The Mitochondrial Basis of Aging
Sun N, et al. The Mitochondrial Basis of Aging. Mol Cell. 2016;61(5):654-666.
Link to Original Publication: https://www.ncbi.nlm.nih.gov/pubmed/26942670
The health and function of mitochondria is important for healthy aging, and strategies to improve mitochondrial function and quality can have far-reaching benefits. Age-related declines in mitochondrial function can be linked to many common complications experienced in older age, including inflammation and declines in both tissue and organ function.
Mitochondrial dysfunction is a key driver of the aging process because as mitochondrial performance declines, this contributes to the decline of other cellular processes important for healthy aging. Evidence suggests that an effective strategy to combat aging could include special actions which improve mitochondrial function and quality control. Examples include interventions to improve mitochondrial biogenesis, increase NAD+ levels or which activate mitophagy to improve mitochondrial function. The future appears to hold promise for developing more solutions that target mitochondrial quality and function to promote healthy aging.