The Hallmarks of Aging
Lopez-Otin C, et al. The Hallmarks of Aging. Cell. 2013;153(6):1194-217.
Link to Original Publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/
Aging is known to be the main factor decreasing the integrity of bodily processes and function, and increasing the threat of disease onset and poor health in older adults. For example, diabetes, heart disease, and cognitive conditions such as Alzheimer's disease manifest from accelerated age-related declines in physiological processes and cellular and metabolic mechanisms.
The nine hallmarks of aging are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The study of these mechanisms and how they are interlinked serves to identify promising targets for future interventions to improve health during aging.