The Impact of Age Associated Cellular Decline on Bioenergetics and Functional Impairment
Goodpaster, B. The Impact of Age Associated Cellular Decline on Bioenergetics and Functional Impairment. Abstract: The 2019 Portuguese Association of Enteral and Parenteral Nutrition (APNEP) Scientific Event at the Nova School of Business and Economics, Lisbon, Portugal. October 4, 2019.
Although each person ages differently, aging is often associated with diminished energy metabolism, reduced physical function, insulin resistance and the onset of type 2 diabetes. Lifestyle habits, such as proper nutrition, regular exercise, and physical activity, promote better mitochondrial function and improved cellular energy metabolism in older adults. On the other hand, a sedentary lifestyle, obesity and inactivity, contribute to mitochondrial dysfunction, reduced muscle function and Age-Associated Cellular Decline (AACD).
It has been demonstrated that increased physical activity and maintaining a healthy body weight can improve mitochondrial energy metabolism and muscle function in older adults. There is a clear opportunity for interventions with healthy nutrition, exercise and physical activity to help increase the number of mitochondria within the cells, maintain better mitochondrial function and prevent some of the negative effects of aging on muscle function.